Elsevier

The Lancet

Volume 387, Issue 10030, 30 April–6 May 2016, Pages 1811-1812
The Lancet

Correspondence
Positive IgM for Zika virus in the cerebrospinal fluid of 30 neonates with microcephaly in Brazil

https://doi.org/10.1016/S0140-6736(16)30253-7Get rights and content

References (4)

  • WHO Director-General summarizes the outcome of the Emergency Committee regarding clusters of microcephaly and Guillain-Barré syndrome

  • RS Lanciotti et al.

    Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007

    Emerg Infect Dis

    (2008)
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  • Are Zika virus cross-reactive antibodies against aquaporin-4 associated to Neuromyelitis Optica Spectrum Disorder?

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    A case series study performed in Brazil by Del Negro et al. reported that only 73.5% of NMO patients exhibited anti-AQP4 IgG antibodies, as determined through ELISA (del Negro et al., 2017). Although unraveling the molecular basis of the ZIKV-associated ON is beyond the scope of this work, our previous studies have shown the presence of ZIKV in the cerebrospinal fluid of neonates born with ZIKV-associated microcephaly (de Araujo et al., 2018; Cordeiro et al., 2016b), which might indicate that the presence of the virus itself is possibly linked to the development of severe neurological phenotypes. Corroborating to this hypothesis, C57BL/6 mice with IFNα/β−/− receptor deletion were infected with ZIKV and monitored for 3 weeks (Fig. 4).

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