Elsevier

Contraception

Volume 13, Issue 4, April 1976, Pages 503-514
Contraception

A d-norgestrel-releasing IUD*

https://doi.org/10.1016/S0010-7824(76)80036-4Get rights and content

Abstract

Steady release of d-norgestrel from an IUD was achieved with a plain Tatum-T-device, the carrier material being sleeves of silasticR. The device was tested in six healthy women, and plasma concentrations of d-norgestrel, estradiol and progesterone were determined for periods of 112–114 days. The values found corresponded to a daily release of 50 μg d-norgestrel. This amount was enough to suppress ovulation. The bleeding pattern was irregular, but the amount of bleeding was reduced. Biopsies showed endometrial hypofunction. The advantage of the intrauterine route of administration of d-norgestrel is discussed.

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*

This study was supported by grants from the Ford Foundation, the Swedish Medical Research Council and the Population Council.

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