Mechanisms of decubitus ulcer formation — An hypothesis
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Cited by (55)
Non-invasive detection of local tissue responses to predict pressure ulcer development in mouse models
2020, Journal of Tissue ViabilityCitation Excerpt :Recent studies have described the in vitro and in vivo mechanisms leading to the development of pressure ulcer. Ischemia [3], ischemia-reperfusion injury [4], impaired interstitial fluid flow and lymphatic drainage [5,6] and cell deformation [7] are considered the four principal pathways associated with pressure ulcer development, and these mechanisms suggest that pressure affects the tissue at a molecular level [8]. The Sebutape method can be utilised to assess the tissue response at the protein level and, in fact, it has been widely used for early detection of pressure ulcers [9].
Prediction of healing in Category I pressure ulcers by skin blotting with plasminogen activator inhibitor 1, interleukin-1α, vascular endothelial growth factor C, and heat shock protein 90α: A pilot study
2019, Journal of Tissue ViabilityCitation Excerpt :VEGF-C is a specific growth factor that promotes lymphangiogenesis [25] and can trigger the healing of Category I PUs. In Category I PU, the vascular system in the dermal layer is injured by an external force and the injuries remain or expand by the accumulation of such anaerobic metabolites and reactive oxygen species [32,33]. In the inflammatory reaction, macrophages secrete several cytokines, including VEGF-C.
Development of a model to demonstrate the effects of friction and pressure on skin in relation to pressure ulcer formation
2017, WearCitation Excerpt :Skin and soft tissue becomes distorted when external friction and/ or pressure are applied to skin surface, this results in compression of the blood vessels. This phenomenon has a physiological effect restricting blood flow, with the restriction in blood flow, perfusion of oxygen is limited and removal of metabolic waste is inhibited which leads to cells death in the affected area resulting in ischemia followed by PU formation [3,4]. The proposed model in the current study demonstrates the effect of friction and pressure to the reduction of cross-sectional areas of blood vessels in the different layers of skin including the dermis and hypodermis.
Early optical diagnosis of pressure ulcers
2015, Biophotonics for Medical ApplicationsSkin microvascular response to pressure load in obese mice
2013, Microvascular ResearchCitation Excerpt :A sustained decrease in blood perfusion and tissue oxygenation was associated with a high occurrence of skin lesions. Krouskop et al. (1978) first hypothesized abnormal blood circulatory patterns and self-tissue poisoning following pressure applications of over 60 mm Hg. The severity of obesity and diabetes did not seem to affect the structure of the cutaneous vessels nor the microvascular response to pressure at 24-h post-release.
Deep Tissue Injury: How Deep is Our Understanding?
2008, Archives of Physical Medicine and Rehabilitation