Is Immunity to malaria really short-lived?

doi:10.1016/0169-4758(92)90174-Z

Parasitology Today

Volume 8, Issue 11, November 1992, Pages 375-378

Parasitology Today

https://doi.org/10.1016/0169-4758(92)90174-Z Get rights and content

Abstract

Protection against Plasmodium falciparum malaria is usually considered to be the cumulative product o f repeated exposure to parasites, and thus a function of age, in endemic areas. The recent outbreak of malaria in the central highlands of Madagascar gave Philippe Deloron and Claire Chougnet the opportunity to compare the incidence of malaria in children and young adults exposed to malaria for the first time, with that in older adults who spent their childhood in the study area before malaria control was introduced. Protection, as well as immune responses to two major P. falciparum antigens, was not related to age. Individuals older than 40 years were more protected than were younger adults. This increased protection was probably due to immunological memory.

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Our results give support to the hypothesis of ‘long-term’ semi-immunity to malaria in VFR living in France.
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FocusIs Immunity to malaria really short-lived?

Abstract

Lancet

Immunol. Lett.

Trans. R. Soc. Trop. Med. Hyg.

Trans. R. Soc. Trop. Med. Hyg.

Trans. R. Soc. Trop. Med. Hyg.

Arch. Inst. Pasteur Madagascar

Bull. WHO

Am. J. Epidemiol.

Am. J. Trop. Med. Hyg.

Am. J. Trop. Med. Hyg.

Focus
Is Immunity to malaria really short-lived?