Scientific paperPrevention of acute gastrointestinal complications after severe head injury: A controlled trial of cimetidine prophylaxis☆,☆☆
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Cited by (129)
Prophylactic acid suppressants in patients with primary neurologic injury: A systematic review and meta-analysis of randomized controlled trials
2022, Journal of Critical CareCitation Excerpt :Of the included trials, 5 (36%) were performed in the United States, 2 were performed in China (14%), 2 were performed in India (14%), and 1 each in Czech Republic, Taiwan, Switzerland, Iran, and Indonesia. A total of 5 trials examined H2RAs compared to placebo [14,27,28,30,36], 2 trials examined H2RAs compared to no intervention [32,37], 1 trial examined PPIs compared to no intervention [29], and 4 trials compared PPIs to H2RAs [26,34,35,38] (See Table 1). Of note, 1 trial examined PPIs and H2RAs as a 3-arm trial with a placebo group [35] and 2 trials compared medications in the same pharmacological class (PPIs) [31,33].
Effects of Yunanan Baiyao adjunct therapy on postoperative recovery and clinical prognosis of patients with traumatic brain injury: A randomized controlled trial
2021, PhytomedicineCitation Excerpt :YB showed significantly better anti-bleeding efficacy (92.30%) than pantoloc (71.20%) in severe TBI-induced stress gastrointestinal bleeding and ulcer (Xu and Ma, 2009; Wang and Dong, 2010) and is more effective in controlling gastrointestinal tract inflammation in colitis model of inflammatory bowel disease (IBD), by suppressing pro-inflammatory cytokine expression (including TNFa, IL-12p40, and IL-17) and T- and B-lymphocytes, and but promoting intestinal epithelial wound-healing/repairing (Li et al., 2011). Gastrointestinal bleeding and dysfunction are common complications of TBI (developed in up to 80% of severe TBI) (Halloran et al., 1980; Gudeman et al., 1983; Muller et al., 1988; Hang et al., 2003). Intracerebral hemorrhage destroys gut mucosa and intestinal barrier, increases plasma levels of malondialdehyde (MDA) and reactive oxygen species (ROS), endotoxin, inflammatory cytokines and oxidative stress, but decreases SOD activity in mice (Cheng et al., 2018).
Acute Management of Traumatic Brain Injury
2017, Surgical Clinics of North AmericaPerioperative Management of Severe Traumatic Brain Injury in Adults
2012, Schmidek and Sweet Operative Neurosurgical Techniques: Indications, Methods, and Results: Sixth EditionGastric Mucosal Defense and Cytoprotection: Bench to Bedside
2008, GastroenterologyCitation Excerpt :Bleeding from these mucosal lesions tends to be slow; if massive bleeding occurs, it suggests that an ulcer (ie, extension below the mucosa) has developed. Overt bleeding (eg, bloody nasogastric aspirate, hematemesis, melena) is reported in ∼20% of critically ill patients; pooled results from placebo/no therapy control groups of 10 randomized controlled trials in metaanalyses of prophylactic therapy performed from 1980 to 1998120,121,123–132 reveal an incidence of 17%. However, the most relevant outcome to consider is clinically significant bleeding.
Stress ulcer prophylaxis in the new millennium: A systematic review and meta-analysis
2010, Critical Care Medicine
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This work was supported by a grant from Smith, Kline and French Laboratories, Philadelphia, Pennsylvania, and Grant NS 12587 from the National Institutes of Health, Bethesda, Maryland.
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Presented at the 20th Annual Meeting of the Society for Surgery of the Alimentary Tract, New Orleans, Louisiana, May 22–23, 1979.
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From the Departments of Surgery and Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia.