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Population pharmacokinetic parameters for bayesian monitoring of amikacin therapy in intensive care unit patients

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Summary

The pharmacokinetics of amikacin has been studied in 40 intensive care unit patients using the bayesian estimation method implemented in the USC PC PACK program of Jelliffe.

The volume of the central compartment was significantly higher in these patients than in the reference population, while other pharmacokinetic parameters did not differ significantly from the reference values.

The population values maybe employed, in addition to those supplied with the software, to adapt dosage regimens of amikacin in ICU patients.

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Authors and Affiliations

  1. Services de Pharmacologie et Toxicologie, Hôpital Dupuytren, 2, avenue Alexis Carrel, F-87042, Limoges, France

    J. Debord, G. Lachatre & C. Gay

  2. Réanimation polyvalente, Chru Dupuytren, Limoges, France

    J. C. Voultoury, J. P. Favereau & R. Gay

Authors
  1. J. Debord
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  2. J. C. Voultoury
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  3. G. Lachatre
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  4. C. Gay
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  5. J. P. Favereau
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  6. R. Gay
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Debord, J., Voultoury, J.C., Lachatre, G. et al. Population pharmacokinetic parameters for bayesian monitoring of amikacin therapy in intensive care unit patients. Eur J Clin Pharmacol 43, 435–436 (1992). https://doi.org/10.1007/BF02220623

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  • DOI: https://doi.org/10.1007/BF02220623

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