Summary
Oral versus intravenous antibiotic therapy of severe erysipelas was compared in a controlled trial of 60 patients. No clinical benefit of intravenous therapy was found, as evaluated by fever duration, hospital stay and sick leave. Untoward reactions were comparable between the groups. No difference in recurrence rate was found. The difference in administration time and drug cost was considerable. It is therefore suggested that erysipelas without complications should be treated orally.
Zusammenfassung
In einer kontrollierten Studie wurde an 60 Patienten ein Vergleich der oralen und intravenösen Therapie des schweren Erysipels vorgenommen. Die intravenöse Therapie zeigte keine klinischen Vorteile in bezug auf Dauer des Fiebers, Krankenhausaufenthalt und Arbeitsunfähigkeit. Die unerwünschten Nebenwirkungen waren bei beiden Gruppen vergleichbar. In den Rückfallquoten fanden sich keine Unterschiede. Die Unterschiede im zeitlichen Aufwand für die Applikation und den Arzneimittelkosten waren beträchtlich. Es wird daher empfohlen, das unkomplizierte Erysipel oral zu behandeln.
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Jorup-Rönström, C., Britton, S., Gavlevik, A. et al. The course, costs and complications of oral versus intravenous penicillin therapy of erysipelas. Infection 12, 390–394 (1984). https://doi.org/10.1007/BF01645222
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DOI: https://doi.org/10.1007/BF01645222