Table 3

Independent predictors of hs-cTnI concentration greater than recommended ULN in final study population (n=18 171)

VariablePredictors of manufacturer troponin ULN >40 ng/L Predictors of non-parametric troponin ULN >189 ng/L
Odds ratio (95% CI)POdds ratio (95% CI)P
Age (per year increase)1.03 (1.03 to 1.04) <0.0011.03 (1.02 to 1.04)<0.001
Male sex1.33 (1.14 to 1.54) <0.0010.90 (0.66 to 123)0.51
Sodium (per unit increase)0.99 (0.97 to 1.01) 0.341.01 (0.97 to 1.04)0.74
eGFR (per unit increase)0.98 (0.97 to 0.98) <0.0010.99 (0.98 to 1.00)0.001
Inpatient location v outpatient
 Emergency department2.79 (2.26 to 3.43) <0.0013.46 (2.14 to 5.61)<0.001
 Resuscitation room9.91 (7.3 to 13.46)<0.00113.79 (7.67 to 24.77)<0.001
 Critical care units36.62 (23.86 to 56.2)<0.00199.27 (55.51 to 177.54)<0.001
 Cardiac wards9.08 (6.44 to 12.81)<0.00114.91 (7.91 to 28.11)<0.001
 Acute surgical unit2.52 (1.47 to 4.33)0.0010.98 (0.13 to 7.21)0.98
 Medical wards4.74 (3.45 to 6.50)<0.0015.80 (2.95 to 11.42)<0.001
 Medicine for older people wards3.70 (2.16 to 6.34) <0.0019.60 (4.00 to 23.00)<0.001
 Orthopaedic wards2.24 (1.23 to 4.05)0.0082.15 (0.51 to 9.14)0.30

eGFR=estimated glomerular filtration rate; hs-cTnI=high sensitivity cardiac troponin I; ULN=upper limit of normal (40 ng/L).