Table 3

Matching estimated odds ratios and 95% confidence interval for associations between antidepressant use during pregnancy and autism spectrum disorder (ASD)

OutcomePropensity score matched analysis*Sibling matched analysis
Exposed/unexposedOR (95% CI)Affected sibling sets/exposedOR (95% CI)
ASD1608/48181.68 (1.23 to 2.30)3038/661.36 (0.84 to 2.20)
ASD without intellectual disability1601/48011.76 (1.26 to 2.46)2408/601.57 (0.92 to 2.66)
ASD with intellectual disability1552/47211.25 (0.52 to 3.03)630/60.78 (0.24 to 2.54)

*Propensity score matched estimates of associations of antidepressant use during pregnancy and ASD in children exposed prenatally to antidepressants compared with children exposed to maternal psychiatric disorder but no antidepressants.

†Outcome discordant sibling matched estimates for associations of antidepressant use during pregnancy and ASD. Conditional logistic regression models adjusted for sex, parity, and birth year.