Table 2

Regression estimated odds ratios and 95% confidence intervals for associations between antidepressant use during pregnancy and autism spectrum disorder (ASD) in children exposed prenatally to antidepressants compared with children exposed to maternal psychiatric disorders but no antidepressants (combined n=15 667) in cluster robust logistic regression models (cluster=birth mother)

Outcome (No of exposed cases)Model 1*Model 2Model 3
ASD (136)1.47 (1.20 to 1.81)1.47 (1.16 to 1.87)1.45 (1.13 to 1.85)
ASD without intellectual disability (122)1.59 (1.28 to 1.98)1.62 (1.25 to 2.08)1.57 (1.21 to 2.04)
ASD with intellectual disability (14)0.87 (0.49 to 1.57)0.81 (0.39 to 1.68)0.72 (0.38 to 1.77)

*Adjusted for birth year.

†Additionally adjusted for maternal psychiatric disorders diagnosed before birth (depression, anxiety disorder, bipolar disorder, non-affective psychotic disorders, obsessive-compulsive disorder, stress related disorders, other neurotic disorders), maternal medications used during pregnancy (antiepileptics, antipsychotics, anxiolytics).

‡Additionally adjusted for sex, maternal age, paternal age, parity, maternal education, family income, maternal birth country.