Table 1

Selected characteristics of Stockholm youth cohort. Figures are numbers (percentage) unless stated otherwise

Exposed to antidepressants during pregnancy (n=3342)Maternal psychiatric disorder and unexposed to antidepressants (n=12 325)No maternal psychiatric disorder and unexposed to antidepressants (n=238 943)
Autism spectrum disorder (ASD)136 (4.1)353 (2.9)4889 (2.1)
 ASD without intellectual disability122 (3.7)291 (2.4)3835 (1.6)
 ASD with intellectual disability14 (0.4)62 (0.5)1054 (0.4)
Mean (SD) maternal age (years)31.7 (5.2)31.5 (5.4)30.7 (5.0)
Mean (SD) paternal age (years)34.0 (6.4)34.0 (6.6)33.7 (6.1)
Male child1727 (51.7)6446 (52.3)122 354 (51.2)
Parity:
 11673 (50.1)5203 (42.2)108 192 (45.3)
 2951 (28.4)4248 (34.5)87 765 (36.7)
 ≥3718 (21.5)2874 (23.3)42 986 (18.0)
Maternal education >12 years1382 (41.3)4897 (39.7)110 017 (46.0)
Family income in highest fifth904 (27.1)3306 (26.8)83 190 (34.8)
Mother born in Sweden2,713 (81.2)9176 (74.5)177 395 (74.2)
Mother smoked512 (15.3)1434 (11.6)16 996 (7.1)
Maternal BMI at 1st antenatal visit:
 Normal (18.5-<25)1741 (52.1)6035 (49.0)129 597 (54.2)
 Underweight (<18.5)81 (2.4)316 (2.6)5590 (2.3)
 Overweight (25-<30)619 (18.5)2272 (18.4)40 212 (16.8)
 Obese (≥30)328 (9.8)981 (8.0)13 945 (5.8)
 Missing573 (17.2)2721 (22.1)49 599 (20.8)
Maternal lifetime psychiatric diagnoses before birth:
 Depression1378 (41.3)5800 (47.1)0
 Anxiety disorder685 (20.5)2594 (21.1)0
 Bipolar disorder70 (2.1)402 (3.3)0
 Non-affective psychoses46 (1.4)645 (5.2)0
 Obsessive-compulsive disorder56 (1.7)139 (1.1)0
 Stress related disorders389 (11.7)4261 (34.6)0
 Other neurotic disorders89 (2.7)1202 (9.8)0
No of diagnoses of maternal depression before birth:
 01964 (58.8)6525 (52.9)238 943 (100)
 1517 (15.5)3287 (26.7)0
 2240 (7.2)1128 (9.2)0
 3172 (5.2)508 (4.1)0
 ≥4449 (13.4)877 (7.1)0
No of diagnoses of maternal depression before birth by treatment:
 Specialist care:
  02337 (69.9)8018 (65.1)238 943 (100)
  1388 (11.6)2493 (20.2)0
  2199 (6.0)952 (7.7)0
  3418 (12.5)862 (7.0)0
 Primary care:
  03059 (91.5)11 766 (95.5)238 943 (100)
  1129 (3.9)286 (2.3)0
  ≥2154 (4.6)273 (2.2)0
 Inpatient diagnosis:
  02,982 (89.2)10 938 (88.8)238 943 (100)
  1229 (6.9)969 (7.9)0
  270 (2.1)233 (1.9)0
  ≥361 (1.8)184 (1.5)0
 Other:
  03201 (95.8)12 042 (97.7)238 943 (100)
  1105 (3.1)232 (1.9)0
  ≥236 (1.1)51 (0.4)0
Medications during pregnancy:
 SSRI antidepressants2710 (81.1)0
 Non-SSRI antidepressants723 (21.6)0
 Antiepileptics37 (1.1)73 (0.6)490 (0.2)
 Antipsychotics106 (3.2)166 (1.4)347 (0.2)
 Anxiolytics314 (9.4)191 (1.6)337 (0.1)