Table 3

 Selective serotonin reuptake inhibitors or venlafaxine in early pregnancy and birth defects. Odds ratios in unmatched and sibling controlled analyses

Type of birth defectFull cohort analysesSibling controlled analyses
Crude odds ratio (95% CI) (n=2 303 647)Adjusted* odds ratio (95% CI) (n=2 145 050)No of familiesNo of infantsNo exposedNo with birth defectsCrude odds ratio (95% CI)Adjusted* odds ratio (95% CI)
Any1.18 (1.12 to 1.24)1.13 (1.05 to 1.20)89522889809231.04 (0.91 to 1.19)1.06 (0.91 to 1.24)
Any cardiac1.30 (1.20 to 1.42)1.15 (1.05 to 1.26)3789914223860.94 (0.76 to 1.16)0.92 (0.72 to 1.17)
Right ventricular outflow tract obstruction1.66 (1.32 to 2.10)1.48 (1.15 to 1.89)4211548420.96 (0.51 to 1.81)0.56 (0.21 to 1.49)

*Adjusted for maternal age, year of birth, birth order, smoking, maternal diabetes, country, and use of other prescribed drugs (antiepileptics (ATC code N03), anxiolytics and hypnotics (N05B and N05C), and angiotensin converting enzyme inhibitors (C09))