Table 4

 Mixed effect meta-regression (unrestricted maximum likelihood) slope effect size, precision, and heterogeneity for the comparisons of albumin with control, crystalloid, and colloid fluid (see online supplement for a more comprehensive version of this table that includes predefined sensitivity and bias subgroup analyses)

CategoryCovariateNo of studiesNo of patientsPoint estimate (95%CI)P valueτ2
Human albumin compared with control fluid
Baseline mortality riskComparison group mortality1641900.0007 (−0.0046 to 0.0061)0.790
Baseline septic shockVasopressor use1240960.0018 (-0.0177 to 0.0544)0.320
Baseline septic shockLactate827420.0136 (−0.0589 to 0.0860)0.710
Baseline hypoalbuminaemiaBaseline albumin level63933−0.0124 (−0.0407 to 0.0159)0.390
Daily intervention exposureDaily albumin dose1541700.0013 (−0.0013 to 0.0038)0.330
Total intervention exposureTotal albumin dose1541700.0006 (−0.0005 to 0.0018)0.260
Early intervention responseDay 1 post-intervention albumin438440.0007 (−0.0454 to 0.0440)0.970
Intervention responsePost-intervention albumin level539000.0173 (−0.0268 to 0.0613)0.440
Intervention responsePost-intervention increase in albumin level539030.0116 (−0.0120 to 0.0352)0.340
Human albumin compared to crystalloid fluid
Baseline mortality riskComparison group mortality738780.0000 (−0.0055 to 0.0054)0.980
Baseline septic shockVasopressor use638540.0018 (−0.0018 to 0.0055)0.330
Baseline septic shockLactate526360.0117 (−0.0895 to 0.0661)0.770
Baseline hypoalbuminaemiaBaseline albumin level43832−0.0 129 (−0.0427 to 0.0189)0.450
Daily intervention exposureDaily albumin dose738780.0003 (−0.0025 to 0.0031)0.820
Total intervention exposureTotal albumin dose738780.0006 (−0.0009 to 0.0022)0.410
Early intervention responseDay 1 post-intervention albumin438320.0074 (−0.0454 to 0.0440)0.970
Intervention responsePost-intervention albumin level438320.0182 (−0.0259 to 0.0624)0.420
Intervention responsePost-intervention increase in albumin level438320.0124 (−0.0114 to 0.0362)0.310
Human albumin compared to colloid fluid
Baseline mortality riskComparison group mortality112990.0022 (−0.0143 to 0.0187)0.790
Baseline septic shockVasopressor use82290.0090 (−0.0162 to 0.0144)0.910
Baseline septic shockLactate5990.0025 (−0.2359 to 0.02409)0.980
Baseline hypoalbuminaemiaBaseline albumin level280NANANA
Daily intervention exposureDaily albumin dose102790.0015 (−0.0032 to 0.0061)0.540
Total intervention exposureTotal albumin dose102790.0004 (−0.0001 to 0.0023)0.640
Early intervention responseDay 1 post-intervention albumin124NANANA
Intervention responsePost-intervention albumin level280NANANA
Intervention responsePost-intervention increase in albumin level280NANANA

NA= not applicable.