Table 3

 Predefined clinical subgroup analysis with relative risk effect size measure using a random effects model (Mantel-Haenszel) and precision for the comparisons of albumin with control, crystalloid, and colloid fluid (see online supplement for a more comprehensive version of this table that includes predefined sensitivity and bias subgroup analyses)

CategorySubgroupsNo of studiesNo of patientsPoint estimate (95%CI)P valueGroup heterogeneitySubgroup difference
I2χ2 P valueI2χ2 P value
Human albumin compared with control fluid
Disease severity (sepsis v severe sepsis and/or septic shock)Severe sepsis and/or septic shock1138540.94 (0.87 to 1.01)0.0900.9600.55
Sepsis53361.15 (0.73 to 1.51)0.8000.79NANA
Disease severity (sepsis v severe sepsis v septic shock)All studies1641900.94 (0.87 to 1.01)0.0800.8800.76
Septic shock419620.92 (0.83 to 1.02)0.1000.45NANA
Severe sepsis820700.95 (0.85 to 1.06)0.3500.67NANA
Sepsis53361.15 (0.73 to 1.51)0.8000.79NANA
Intervention methodPredefined426910.95 (0.87 to 1.05)0.3100.7700.64
Variable1614990.92 (0.81 to 1.04)0.1800.96NANA
Intervention typeHypooncotic (4-5% albumin)713630.90 (0.79 to 1.03)0.1300.9200.47
Hyperoncotic (20% albumin)928270.96 (0.87 to 1.05)0.3500.92NANA
Intervention timingEarly (<24 hours)639070.93 (0.86 to 1.01)0.1000.8900.69
Not described/other timing102830.98 (0.80 to 1.20)0.8200.93NANA
Time of mortality observation90 day226020.95 (0.87 to 1.05)0.3200.6900.72
28-30 day313070.88 (0.75 to 1.02)0.0900.58NANA
Hospital51220.99 (0.78 to 1.26)0.9600.80NANA
ICU61601.03 (0.72 to 1.48)0.8800.86NANA
Human albumin compared to crystalloid fluid
Disease severity (sepsis v severe sepsis and/or septic shock)Severe sepsis and/or septic shock738780.93 (0.86 to 1.01)0.0700.98NANA
Sepsis00NANANANANANA
Disease severity (sepsis v severe sepsis v septic shock)All studies738780.93 (0.86 to 1.000.0500.6300.56
Septic shock419490.91 (0.82 to 1.010.0600.77NANA
Severe sepsis419290.96 (0.83 to 1.10)0.5500.29NANA
Sepsis00NANANANANANA
Intervention methodPredefined226020.95 (0.87 to 1.05)0.3200.6900.32
Variable512760.88 (0.77 to 1.01)0.0801.00NANA
Intervention typeHypooncotic (4-5% albumin)512760.88 (0.77 to 1.01)0.0801.0000.33
Hyperoncotic (20% albumin)226020.95 (0.87 to 1.05)0.3200.69NANA
Intervention timingEarly (<24 hours)438320.93 (0.86 to 1.01)0.1200.7800.93
Not described/other timing3460.92 (0.71 to 1.20)0.5300.99NANA
Time of mortality observation90 day226020.95 (0.87 to 1.05)0.3200.6900.82
28-30 day112180.87 (0.74 to 1.02)0.09NANANANA
Hospital3460.92 (0.71 to 1.20)0.5300.99NANA
ICU1121.00 (0.20 to 4.95)1.00NANANANA
Human albumin compared to colloid fluid
Disease severity (sepsis v severe sepsis and/or septic shock)Severe sepsis and/or septic shock71411.04 (0.68 to 1.59)0.8600.7100.98
Sepsis51581.05 (0.73 to 1.51)0.8000.79NANA
Disease severity (sepsis v severe sepsis v septic shock)All studies112991.04 (0.79 to 1.38)0.7600.928.00.34
Septic shock2271.54 (0.78 to 3.01)0.2100.82NANA
Severe sepsis41140.80 (0.46 to 1.39)0.4300.90NANA
Sepsis51581.05 (0.73 to 1.51)0.8000.79NANA
Intervention methodPredefined2980.77 (0.38 to 1.53)0.4500.5400.34
Variable92011.11 (0.82 to 1.50)0.5100.92NANA
Intervention typeHypooncotic (4-5% albumin)51071.13 (0.74 to 1.74)0.5700.8300.62
Hyperoncotic (20% albumin)61920.99 (0.69 to 1.41)0.9400.74NANA
Intervention timingEarly (<24 hours)2481.04 (0.45 to 2.42)0.9300.6100.99
Not described/other timing92511.05 (0.78 to 1.40)0.7700.84NANA
28-30 day1560.58 (0.18 to 1.83)0.35NANANANA
Hospital4891.18 (0.75 to 1.86)0.4700.76NANA
ICU61541.02 (0.71 to 1.47)0.9000.85NANA
Colloid type: HES6% tetrastarch 130 kDa2760.65 (0.28 to 1.51)0.3200.7626.30.24
Other 92231.11 (0.83 to 1.48)0.5000.93NANA
Colloid type: gelatinGelatin1121.00 (0.20 to 4.95)1NANANANA

NA= not applicable. ICU=intensive or critical care unit. HES= hydroxyethyl starch.