Table 1

 Characteristics of 16 randomised critical care studies reported in 18 articles included in meta-analysis, and baseline patient characteristics of the albumin intervention group (or study population). Further study information available in data supplement

StudyStudy characteristicsDiagnosisNo of patients (% male)Baseline characteristics of patients in albumin intervention group
Age (years)Serum lactate level (mmol/L)Vasopressor use (%)Serum albumin level (g/L)
ALBIOS 201438100 centres; Italy; Aug 2008 to Feb 2012Severe sepsis; septic shock1810 (60.1)Median 70.0 (IQR 57-77)Median 2.3 (IQR 1.4-4.2)62.6Mean 24.1 (6.3)
Boldt et al 1995751 centre; GermanySepsis*30Median 59.3 (range 40-74)
Boldt, Heesen, et al 1996741 centre; GermanySepsis*30Mean 54.8 (SD 10.8)Mean 1.7 (SD 0.4)21.4
Boldt, Müller, et al 1996761 centre; GermanySepsis*28 (64.3)Mean 57.5 (SD 12.3)85.7
Boldt, Muller, et al 1996771 centre; GermanySepsis*28Mean 61.0 (SD 10.1)53.3
Dolecek et al 2009781 centre; Czech Republic; May 2005 to Feb 2008Severe sepsis†56 (86.7)Median 47.0 (range 19 to 81)60.0Mean 23.8 (SD 5.9)
EARSS 20113729 centres; France; Jul 2006 to Mar 2010Septic shock792 (65.7)Median 66.0 (IQR 55-76)Median 0.2 (IQR 0.2-0.4)100Median 17.8 (IQR 14-12)
Friedman et al 2008791 centre; BelgiumSepsis42 (38.4)Mean 66.0 (SD 14)84.6
Haupt et al 1982801 centre; USASeptic shock17 (71.4)Mean 76.0 (SD 12.8)Mean 6.6 (SD 6.0)100
Metildi et al 1984811 centre; USA; Jun 1978 to May 1979Severe sepsis‡24 (66.7)Mean 45.0 (SD 20.5)
Palumbo et al 2006821 centre; ItalySevere sepsis; septic shock20 (50.0)Mean 59.6 (SD 12.6)§
Rackow et al 1983831 centre; USA; Oct 1979 to Jun 1980Septic shock18 (71.4)Mean 76.0 (SD 12.8)Mean 6.0 (SD 1.8)§100
Rackow et al 1989841 centre; USASevere sepsis20 (80.0)Mean 65.1 (SD 13)Mean 5.6 (SD 1.4)
SAFE 20047, 2011816 centres; Australasia; Nov 2001 to Jun 2003Severe sepsis; septic shock1218 (59.6)Mean 60.5 (SD 17.2)34.8Mean 25.0 (SD 7.2)
Van der Heijden et al 200986, Trof et al 2010851 centre; NetherlandsSevere sepsis24 (66.7)Mean 60.0 (SD 9)Mean 2.0 (SD 0.9)67.0§Mean 11 (SD 2)
Veneman et al 2004871 centre; NetherlandsSevere sepsis33 (27)¶; 53.3§Mean 72.0§Mean 1.3 (SD 40.2)§50.0§Mean 15 (SD 1)§

IQR=interquartile range; SD=standard deviation; — =value unclear or not reported.

*Patients with septic shock excluded.

†Extravascular lung water >7 mL/kg.

‡Moderate to severe acute respiratory distress syndrome.

§Data from study population.

¶Sepsis group patients originally reported87 at odds with data supplied by the authors.22