Table 3

 Outcomes after propensity score matched landmark analyses

AnalysisExposure period (years)No in groupCardiovascular event
Hazard ratio (95% CI)P value
Primary31530.56 (0.43 to 0.74)<0.001
Knee only*3940.46 (0.29 to 0.75)0.0017
Hip only†3490.61 (0.38 to 0.99)0.0442
Subgroup‡31220.71 (0.53 to 0.96)0.0273
Sensitivity§21260.67 (0.50 to 0.90)0.0078
Sensitivity¶41790.57 (0.44 to 0.74)<0.001

*Excluded people who underwent total hip arthroplasty.

†Excluded people who underwent total knee arthroplasty.

‡Analysis done in patients with at least one risk factor for cardiovascular disease (diabetes, hypertension, or pre-existing cardiovascular disease), with an exposure window of three years.

§Analysis with exposure window of two years.

¶Analysis with exposure window of four years.