Table 2

Pair-wise odds ratios between seven treatments for acute myocardial infarction obtained by direct and multiple treatment comparisons with fixed effect and random effects analyses*

Fixed effectRandom effects
Treatment comparisonDirect comparisonsMultiple comparisonDirect comparisonsMultiple comparison
Streptokinase v:
Alteplase1.00 (0.94 to 1.06)0.99 (0.94 to 1.06)0.89 (0.54 to 1.14)0.96 (0.74 to 1.10)
Accelerated alteplase0.86 (0.78 to 0.94)0.86 (0.78 to 0.93)0.84 (0.68 to 0.99)
Streptokinase+alteplase0.96 (0.87 to 1.05)0.96 (0.87 to 1.05)0.97 (0.75 to 1.25)
Reteplase0.95 (0.79 to 1.12)0.90 (0.80 to 1.01)0.88 (0.65 to 1.06)
Tenecteplase0.86 (0.74 to 1.00)0.85 (0.57 to 1.17)
PCTA0.52 (0.36 to 0.73)0.63 (0.52 to 0.77)0.49 (0.20 to 0.91)0.62 (0.47 to 0.77)
Alteplase v:
Accelerated alteplase0.86 (0.77 to 0.95)0.88 (0.70 to 1.19)
Streptokinase+alteplase0.96 (0.86 to 1.07)1.02 (0.78 to 1.51)
Reteplase0.90 (0.79 to 1.02)0.92 (0.70 to 1.24)
Tenecteplase0.86 (0.73 to 1.01)0.90 (0.61 to 1.35)
PCTA0.63 (0.25 to 1.29)0.64 (0.51 to 0.77)0.65 (0.49 to 0.86)
Accelerated alteplase v:
Streptokinase+alteplase1.12 (1.00 to 1.25)1.12 (1.01 to 1.24)1.16 (0.91 to 1.55)
Reteplase1.02 (0.90 to 1.16)1.05 (0.94 to 1.17)1.04 (0.81 to 1.28)
Tenecteplase1.01 (0.88 to 1.14)1.01 (0.89 to 1.14)1.01 (0.74 to 1.35)
PCTA0.81 (0.64 to 1.02)0.74 (0.61 to 0.89)0.79 (0.55 to 1.05)0.73 (0.59 to 0.90)
Streptokinase+alteplase v:
Reteplase0.94 (0.82 to 1.07)0.92 (0.62 to 1.19)
Tenecteplase0.90 (0.76 to 1.05)0.89 (0.57 to 1.27)
PCTA0.66 (0.53 to 0.81)0.64 (0.45 to 0.85)
Reteplase v:
Tenecteplase0.96 (0.82 to 1.13)0.98 (0.68 to 1.43)
PCTA0.71 (0.57 to 0.87)0.71 (0.53 to 0.94)
Tenecteplase v PCTA0.74 (0.58 to 0.92)0.74 (0.50 to 1.03)
  • PCTA= primary percutaneous transluminal coronary angioplasty.

  • * Empty cells represent pair-wise comparisons that have not been evaluated in trials (fixed effect) or for which there are fewer than three trials (random effects).