Table 1.

Details of the 354 trials of blood pressure lowering drugs (adapted from Law et al7)

TreatmentPlacebo
No of participants (No of different drugs) in trials of:
Thiazides (7)4 5022 636
βblockers (15)5 1892 701
ACE inhibitors (12)9 3504 712
Angiotensin II receptor antagonists (8)12 8405 100
Calcium channel blockers (11)7 9983 976
All trials39 87915 817*
No of treatment groups within trials of:
Thiazides10464
βblockers13676
ACE inhibitors217114
Angiotensin II receptor antagonists12554
Calcium channel blockers209122
All trials791354*
Trial design:
Crossover219125
Parallel group572229
Mean (90% range) pretreatment blood pressure (mm Hg):
Systolic154 (139-170)154 (139-170)
Diastolic97 (87-106)97 (87-106)
Median (90% range) duration (weeks)4 (2-12)4 (2-12)
Mean (90% range) age (years)53 (43-68)53 (43-68)
  • ACE=angiotensin converting enzyme

  • *Less than total of five categories because some trials compared drugs from two or more categories with the same placebo group