Table 1

Selected ongoing phase I, II, and III cancer prevention trials sponsored by the US National Cancer Institute

Target organAgent
Phase I trials
 BreastL-Perillyl alcohol
Selective oestrogen receptor modulators-3 (2 trials)
Soy isoflavones
ColonCurcumin
Ursodiol
LungPhenethyl isothiocyanate
L-Selenomethionine and vitamin E
ProstateLycopene (3 trials)
Soy isoflavones
SkinEpigallocatechin gallate and polyphenon E
Phase II trials
 Anogenital warts, human papillomavirus, HIVIndole-3-carbinol
Barrett's oesophagusCelecoxib
2-Difluoromethylornithine
BladderCelecoxib
Breast2-Difluoromethylornithine (2 trials)
Exemestane
L-Perillyl alcohol
Selective oestrogen receptor modulators-3 (2 trials)
Tamoxifen (2 trials)
Tamoxifen and N-(4-hydroxyphenyl) retinamide (2 trials)
Targretin
Cervix9-cis-Retinoic acid
2-Difluoromethylornithine
N-(4-hydroxyphenyl) retinamide
ColonCelecoxib (2 trials)
Celecoxib and 2-difluoromethylornithine
2-Difluoromethylornithine and sulindac
Folic acid
Vitamin D and calcium
EndometriumMedroxyprogesterone v depo-provera
LiverOltipraz
LungAnetholetrithione
Budesonide
MouthCelecoxib
N-(4-hydroxyphenyl) retinamide
OvaryN-(4-hydroxyphenyl) retinamide and oral contraceptive
ProstateCelecoxib
2-Difluoromethylornithine
2-Difluoromethylornithine and casodex
Flutamide
Flutamide and luprolide
Flutamide and toremifene
N-(4-hydroxyphenyl) retinamide
Selenised yeast
Soy (dietary)
Soy isoflavones
Vitamin D analogue
SkinCelecoxib
Polyphenon E (wartheal)
Sulindac
Phase III trials
 Bladder2-Difluoromethylornithine
N-(4-hydroxyphenyl) retinamide
BreastRaloxifene and tamoxifen
ColonCelecoxib
OesophagusL-Selenomethionine and celecoxib
ProstateFinasteride
Selenomethionine
Selenium and vitamin E
Skin2-Difluoromethylornithine
N-(4-hydroxyphenyl) retinamide