Table 6

 Effect of dose on measures of respiratory compromise, expressed as Kaplan Meier estimates and 95% confidence intervals, in study of double or standard dose oseltamivir for treatment of severe influenza

Double doseStandard doseP value*
Receipt of oxygen
Median (IQR) time (days)3 (2-5)3.5 (2-7)0.48†
No of patients5048
% on oxygen on day 355.5 (39.7 to 68.7)60.5 (44.1 to 73.4)0.72‡
% on oxygen on day 536.3 (21.7 to 51.1)42.8 (26.8 to 57.8)
% on oxygen on day 722.7 (9.6 to 39.1)28.5 (14.4 to 44.4)
% on oxygen on day 1017.0 (5.4 to 34.1)28.5 (14.4 to 44.4)
Time in intensive care unit (ICU)
Median (IQR) time (days)4.5 (3-6)5 (2-11)0.66†
No of patients2734
% in ICU on day 384.7 (64.0 to 94.0)77.1 (57.8 to 88.5)0.57‡
% in ICU on day 547.4 (23.0 to 68.4)60.9 (40.1 to 76.4)
% in ICU on day 737.9 (14.5 to 61.5)38.8 (18.7 to 58.5)
% in ICU on day 1025.3 (5.3 to 52.5)33.2 (14.5 to 53.3)
Time on ventilation
Median (IQR) time (days)2.5 (1-16)8 (1-16)0.58†
No of patients1921
% on ventilation on day 389.5 (64.1 to 97.3)85.7 (62.0 to 95.2)0.68‡
% on ventilation on day 571.6 (26.1 to 92.0)75.0 (42.4 to 90.8)
% on ventilation on day 771.6 (26.1 to 92.0)75.0 (42.4 to 90.8)
% on ventilation on day 1071.6 (26.1 to 92.0)45.0 (11.9 to 74.1)

*For comparison between arms.

†Kruskal-Wallis test.

‡Log rank test.