Table 6

Sensitivity by serology test method and timing in relation to onset of symptoms*†

Time post-onsetIgMIgG
No of armsTPFNPooled sensitivity (95% CI)No of armsTPFNPooled sensitivity (95% CI)
ELISA:        
 First week4369926.7 (15.6 to 35.6)53913323.7 (12.7 to 38.1)
 Second week51698057.6 (15.9 to 88.2)61659165.3 (46.3 to 79.4)
 Third week or later51463278.4 (54.1 to 91.9)61653682.1 (76.4 to 89.0)
LFIA:        
 First week1510530125.3 (16.3 to 31.1)157432913.4 (4.7 to 29.6)
 Second week1547126551.8 (30.3 to 69.6)1544231250.1 (24.8 to 77.0)
 Third week or later1530415269.9 (58.4 to 79.9)153619579.7 (71.4 to 86.9)
CLIA:        
 First week5281950.3 (10.9 to 81.2)5252253.2 (28.7 to 67.6)
 Second week4703374.3 (16.1 to 99.4)4821885.4 (48.1 to 98.1)
 Third week or later52804490.6 (51.8 to 99.4)5321798.9 (86.9 to 100)

Ig=immunoglobulin; TP=true positive; FN=false negative; ELISA=enzyme linked immunosorbent assay; LFIA=lateral flow immunoassay; CLIA=chemiluminescent immunoassay.

  • * First week range: 0-7 days (one cohort reporting 0-10 days is counted here), second week: 7-14 days, third week: 15 days or more.

  • Pooled estimates were calculated using univariate random effects meta-analysis, which is why they depart from estimates calculated by simple division of true positives by the sum of true positives and false negatives.