Supplementary Table 1[As supplied by authors]. Studies excluded from the review

Study reference

Reason for exclusion

1. Becker A, Buck W, Vogtle-Junkert U. Analgesia and antiemesis as therapeutic aims in the treatment of migraine. Medizinische Welt 1988;39:473-476.

Patients received oral treatment

2. Brito Neto AJ. [Evaluation of therapeutic efficacy and tolerability of an association including ergot compound, analgesic and antiemetic for treatment of migraine attacks] [Portuguese]. Revista Brasileira de Medicina. 1993;50:89-94.

Patients were not randomly assigned to treatment arms

3. Chabriat H, Joire JE, Danchot J, Grippon P, Bousser MG. Combined oral lysine acetylsalicylate and metoclopramide in the acute treatment of migraine: a multicentre double-blind placebo-controlled study. Cephalalgia 1994;14:297-300.

Patients received oral treatment

4. Cunha J, Brito Neto AJ. Evaluation of therapeutic efficacy and tolerability of the association dihydroergotamine, paracetamol, metoclopramide for migraine attacks. Revista Brasileira de Medicina 1994;51:767-773.

Patients were not randomly assigned to treatment arms

5. Dexter SL, Graham AN, Johnston ES, Ratcliffe DM, Wilkinson MI, Rose AJ. Double-blind controlled study of paramax in the acute treatment of common and classical migraine. British Journal of Clinical Practice 1985;39:388-392.

Patients received oral treatment

6. Geraud G, Compagnon A, Rossi A. Zolmitriptan versus a combination of acetylsalicylic acid and metoclopramide in the acute oral treatment of migraine: a double-blind, randomised, three-attack study. European Neurology 2002;47:88-98.

Patients received oral treatment

7. Hakkarainen H, Parantainen J, Gothoni G, Vapaatalo H. Tolfenamic acid and caffeine: a useful combination in migraine. Cephalalgia 1982;2:173-177.

Patients received oral treatment

8. Hakkarainen H. Ergotamine vs. metoclopramide vs. their combination in acute migraine attacks. Headache 1982;22:10-12.

Patients received suppository treatment

9. Henry P, Hiesse-Provost O, Dillenschneider A, Ganry H, Insuasty J. [Efficacy and tolerance of an effervescent aspirin-metoclopramide combination in the treatment of a migraine attack: a randomized double-blind study using a placebo] [French]. Presse Medicale 1995;24:254-258.

Patients received oral treatment

10. Jovicic A, Maric D, Ilic T. [Treatment of acute migraine attacks] [Serbo-Croatian (Roman)]. Vojnosanitetski Pregled 1995;52:44-48.

Patients were not randomly assigned to treatment arms

11. Klapper J, Stanton J. The emergency treatment of acute migraine headache: A comparison of intravenous dihydroergotamine, dexamethasone, and placebo. Cephalalgia 1991;11:159-160.

Both treatment arms received the same dosage of metoclopramide. A third treatment arm received placebo, however the first two treatment arms received metoclopramide with other treatments - metoclopramide plus other agents versus placebo was not considered useful for this review.

12. Le Jeunne C, Gomez JP, Pradalier A, Albareda F, Joffroy A, Liano H, Henry P, Lainez JM, Geraud G. Comparative efficacy and safety of calcium carbasalate plus metoclopramide versus ergotamine tartrate plus caffeine in the treatment of acute migraine attacks. European Neurology 1999;41:37-43.

Patients received oral treatment

13. Lipton RB, Stewart WF, Stone AM, Lainez MJ, Sawyer JP. Stratified care vs step care strategies for migraine: the Disability in Strategies of Care (DISC) Study: A randomized trial. JAMA 2000;284:2599-2605.

Patients received oral treatment

14. Matts SG. Metoclopramide in the treatment of migraine. Practitioner 1974;212:887-890.

Patients received oral treatment

15. Pradalier A, Guerard des Lauriers A, Scheck F, Peraudeau P, Lacoste JP, Cajfinger F. [Calcium carbasalate-metoclopramide combination versus dihydroergotamine in the treatment of migraine attacks] [French]. Pathologie et Biologie 1995;43:806-813.

Patients received oral treatment

16. Schulman EA, Dermott KF. The efficacy of sumatriptan plus metoclopramide in migraine patients who were triptan non-responsive. Cephalalgia 2001;21:417.

Patients received oral treatment

17. Tfelt-Hansen P, Olesen J. Effervescent metoclopramide and aspirin (Migravess) versus effervescent aspirin or placebo for migraine attacks: a double-blind study. Cephalalgia 1984;4:107-111.

Patients received oral treatment

18. Tfelt-Hansen P, Henry P, Mulder LJ, Scheldewaert RG, Schoenen J, Chazot G. The effectiveness of combined oral lysine acetylsalicylate and metoclopramide compared with oral sumatriptan for migraine. Lancet 1995;346:923-926.

Patients received oral treatment

19. The Oral Sumatriptan and Aspirin plus Metoclopramide Comparative Study Group. A study to compare oral sumatriptan with oral aspirin plus oral metoclopramide in the acute treatment of migraine. European Neurology 1992;32:177-184.

Patients received oral treatment

20. Titus F, Escamilla C, Gomes Da Costa Palmeira MM, Leira R, Pereira Monteiro JMP. A double-blind comparison of lysine acetylsalicylate plus metoclopramide vs ergotamine plus caffeine in migraine: Effects on nausea, vomiting and headache symptoms. Clinical Drug Investigation 2001;21:87-94.

Patients received oral treatment

21. Tokola RA, Kangasniemi P, Neuvonen PJ, Tokola O. Tolfenamic acid, metoclopramide, caffeine and their combinations in the treatment of migraine attacks. Cephalalgia 1984;4:253-263.

Patients received oral treatment