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Cohort study on effects of parathyroid surgery on multiple outcomes in primary hyperparathyroidism

BMJ 2003; 327 doi: https://doi.org/10.1136/bmj.327.7414.530 (Published 04 September 2003) Cite this as: BMJ 2003;327:530

Data supplement

  •  
    Table A

    Table B

    Table A Codes used in the ICD8 and ICD10 system for identifying patients with selected outcomes [As supplied by authors]
     

    OutcomeICD codes
    Fractures80099, 80100-80109, 80210-80299, 80399, 80500-80599, 81099, 81199, 81200-81299, 81300-81399, 81400-81409, 81500-81509, 81600-81604, 81899, 82000-82009, 82109-82199, 82300-82399, 82400-82409, 82500-82509, 82600-82609, 82799, S020-S029, S120-S129, S220-S221, S320-S328, S420-S429, S520-S529, S620-S628, S720-S729, S821-S829, S920-S929
    Osteoporosis72309, M800-M809, M810-M819
    Kidney and urinary tract stones59200-59209, N200-N209
    Acute myocardial infarction41009, 41099, I210-I219, I220-I229
    Angina pectoris41309, 41399, I200-I209
    Cardiac arrhythmias42720-42797, I440-I447, I450-I459, I470-I479, I489, I490-I499
    Arterial hypertension40199, I109
    Heart failure42709-42799, I500-I509
    Stroke43100-43199, 43309-43399, 43409-43499, 43690, I610-I619, I630-I639, I649
    Gastric ulcers53100-53199, 53209-53299, 53309-53399, 53409-53499, K250-K259, K260-K269, K270-K279, K280-K289
    Acute pancreatitis57700-57709, 57711-57719, K859, K861
    Muscle pain71709, 71799, M544-M549
    Cancer40.00-207.99, ICD10 codes starting with C and D00.0-D09.9
    Psychiatric diseases29000-29999, F000-F390
    Neuroses30000-30999, F400-F510
    Parathyroid surgery codes0842, 08420, 0844, 08440, 08450, 0846, 08460, 0856, 08560, 08570, KBBA10, KBBA20, KBBA30, KBBA40, KBBA50, KBBA70, and KBBA99

     

    Table B Calculation of risk in surgically treated vs. conservatively treated with exclusion of those who had experienced an end-point before the time of diagnosis. The numbers in the columns "Surgery" and "No surgery" are number with end-point and total number [As supplied by author]
     

    Parameter
    Surgery
    No surgery
    Crude OR
    HR of age (1)
    HR of gender (2)
    HR of surgery (3)
    Fractures
    204/1762
    124/1103
    1.03 (0.82-1.31)
    2.13 (1.60-2.84)
    1.97 (1.44-2.69)
    0.76 (0.60-0.95)
    Kidney stones
    67/1637
    23/1196
    2.18 (1.36-3.48)
    0.57 (0.37-0.88)
    0.80 (0.50-1.28)
    1.65 (1.02-2.65)
    Stroke
    120/1896
    69/1233
    1.14 (0.84-1.55)
    6.49 (3.74-11.26)
    0.86 (0.61-1.20)
    0.81 (0.60-1.10)
    Hypertension
    81/1849
    26/1221
    2.11 (1.36-3.26)
    1.16 (0.76-1.78)
    0.74 (0.49-1.13)
    1.48 (0.95-2.30)
    AMI
    86/1869
    40/1204
    1.40 (0.96-2.05)
    3.84 (2.25-6.56)
    0.50 (0.34-0.72)
    1.03 (0.71-1.50)
    Angina
    81/1875
    39/1229
    1.38 (0.94-2.03)
    2.78 (1.73-4.47)
    0.40 (0.28-0.58)
    0.97 (0.66-1.42)
    Heart failure
    80/1905
    48/1237
    1.09 (0.75-1.56)
    6.37 (3.21-12.65)
    0.87 (0.58-1.32)
    0.81 (0.57-1.17)
    Arrhythmias
    82/1879
    32/1229
    1.71 (1.13-2.57)
    2.45 (1.50-4.02)
    0.65 (0.44-0.98)
    1.28 (0.85-1.92)
    Pancreatitis
    10/1896
    6/1270
    1.12 (0.41-3.08)
    0.53 (0.19-1.48)
    0.39 (0.14-1.07)
    0.82 (0.30-2.25)
    Ulcers
    59/1835
    47/1223
    0.83 (0.56-1.23)
    2.51 (1.49-4.23)
    0.74 (0.48-1.13)
    0.60 (0.41-0.88)
    Muscle pain
    33/1911
    24/1245
    0.89 (0.53-1.52)
    1.38 (0.73-2.61)
    1.72 (0.84-3.55)
    0.66 (0.39-1.13)
    Osteoporosis
    27/1899
    24/1252
    0.74 (0.42-1.28)
    8.94 (2.16-37.00)
    4.27 (1.33-13.75)
    0.59 (0.34-1.03)
    Cancer
    220/1799
    89/1160
    1.68 (1.30-2.17)
    2.84 (2.07-3.89)
    0.72 (0.56-0.92)
    1.24 (0.96-1.58)
    Psychiatric dis.
    43/1911
    28/1250
    1.00 (0.62-1.63)
    2.77 (1.40-5.48)
    0.92 (0.53-1.59)
    0.76 (0.47-1.22)
    Neuroses
    17/1901
    13/1243
    0.85 (0.41-1.76)
    0.57 (0.27-1.21)
    2.44 (0.84-7.08)
    0.64 (0.31-1.32)

    (1) Hazard rate for the end-point in question of age group ³ 50 vs. <50 years at diagnosis in a Cox model, e.g. was the fracture risk 1.90 times higher in the age-group ³ 50 than in the age group <50 years, (2) Hazard rate in males versus females for the end-point in question, (3) Hazard rate in surgically treated versus conservatively treated. The hazard rates are mutually adjusted.
     

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