Research Article

Histological evidence of carcinoma in a hepatic tumour associated with oral contraceptives.

Br Med J 1975; 4 doi: (Published 29 November 1975) Cite this as: Br Med J 1975;4:496
  1. M Davis,
  2. B Portmann,
  3. M Searle,
  4. R Wright,
  5. R Williams


    A primary hepatic tumour occurred in a 21-year-old woman who had been taking oral contraceptives for two years; she was treated by partial hepatectomy. Part of the neoplasm showed features suggestive of focal nodular hyperplasia, while the remainder had the histological characteristics of a well-differentiated hepatocellular carcinoma. This is the first report of malignant transformation of a tumour in a patient taking oral contraceptives.