Research Article

Free erythrocyte protoporphyrin level and nerve conduction velocity in end-stage renal disease.

Br Med J 1975; 4 doi: (Published 08 November 1975) Cite this as: Br Med J 1975;4:324
  1. G M London,
  2. Y Nordmann,
  3. M E Safar,
  4. S Métral,
  5. P Milliez


    Increased free erythrocyte protoporphyrin concentrations and depressed motor nerve conduction velocities (MNCV) were observed in 45 patients on maintenance haemodialysis. Neither of these findings could be correlated with age, duration or frequency of dialysis, or the degree of uraemia present. A strong negative correlation (r=--0-53; P less than 0-001), however, existed between the free erythrocyte protoporphyrin level and the MNCV, which suggested either (a) a direct effect of iron status on nerve function, or (b) a toxic factor in "uraemia" that depresses both nerve conduction and haemsynthetase activity.