Intended for healthcare professionals

Papers And Originals

Neonatal Hyperthyroidism and Long-acting Thyroid Stimulator Protector

Br Med J 1974; 4 doi: (Published 21 December 1974) Cite this as: Br Med J 1974;4:695
  1. J. Nutt,
  2. F. Clark,
  3. R. G. Welch,
  4. R. Hall


    Neonatal hyperthyroidism has been thought to result from transplacental passage of long-acting thyroid stimulator (L.A.T.S.) from a mother with Graves's disease. A case is presented here in which no L.A.T.S. was detected in the mother or neonate but another immunoglobulin, L.A.T.S. protector, a specific human thyroid stimulator, was shown to be present in the mother's serum. This stimulator may have been the cause of the neonatal hyperthyroidism.