Papers And Originals

Haemoglobin Belfast 15 (A12) Tryptophan→Arginine: A New Unstable Haemoglobin Variant

Br Med J 1974; 4 doi: (Published 09 November 1974) Cite this as: Br Med J 1974;4:324
  1. C. Cotton Kennedy,
  2. Gillian Blundell,
  3. P. A. Lorkin,
  4. A. Lang,
  5. H. Lehmann


    A new unstable haemoglobin, α2β215 Trp→ Arg (Hb Belfast), with increased oxygen affinity has been found during the routine investigation of a long-stay psychiatric patient. It seemed to cause little haematological disorder. The reticulocytes synthesized normal and abnormal β-chains at the same rate but in the circulating blood Hb Belfast amounted to only 27·5% of the total haemoglobin.