Medical Practice

Variability in Response to Drugs

Br Med J 1974; 4 doi: (Published 12 October 1974) Cite this as: Br Med J 1974;4:91
  1. Michael D. Rawlins


    Variability in the response to drugs is due to three principal components—the disease, the responsiveness of tissues, and the concentration of the drug at its site of action (as reflected by its plasma concentration). The relative contributions of these components will differ not only for different drugs but also for different effects of the same drug. Rational drug therapy depends on knowledge of all three factors.


    • * Based on the inaugural lecture of the Ruth and Lionel Jacobson Professor of Clinical Pharmacology delivered at the University of Newcastle upon Tyne on 22 January 1974.

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