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Use of 5-Fluorocytosine in Patients with Impaired Renal Function

Br Med J 1973; 4 doi: (Published 17 November 1973) Cite this as: Br Med J 1973;4:382
  1. J. K. Dawborn,
  2. M. D. Page,
  3. D. J. Schiavone


    The plasma level and elimination of 5-fluorocytosine (5-FC) was measured in normal subjects and patients with impaired renal function. Prolongation of the half-life of the drug in renal failure has been confirmed. Renal clearance of 5-FC was about 75% of the creatinine clearance and a corresponding modification of drug dosage should be made in patients with renal insufficiency.