Papers And Originals

Renal Response to Acid Load after Phenformin

Br Med J 1973; 4 doi: (Published 03 November 1973) Cite this as: Br Med J 1973;4:256
  1. Gösta Rooth,
  2. Ulf Bandman


    Normally the kidneys respond to an acid load by increased ammonia production. In six patients with adult-type diabetes this response was reduced by a mean 50% after a therapeutic dose of phenformin. The reduced ability to compensate for acid loads may be one factor leading to metabolic acidosis and lactoacidosis sometimes associated with phenformin therapy.