Papers And Originals

Benign Obstetric History in Women with Sickle-cell Anaemia Associated with α-Thalassaemia

Br Med J 1972; 4 doi: (Published 02 December 1972) Cite this as: Br Med J 1972;4:524
  1. A. van Enk,
  2. A. Lang,
  3. J. M. White,
  4. H. Lehmann


    Two Ghanaian women with sickle-cell anaemia and α-thalassaemia were found to have an unusually benign obstetric history. In addition to two factors present which are known to moderate the clinical course of sickle-cell anaemia, good socioeconomic status and a relatively high Hb F level, it is suggested that α-thalassaemia may act among other things by lowering the haemoglobin concentration in the red cells and thereby lowering their tendency to sickle in vivo.