Papers And Originals

Induction of Labour by Simultaneous Intravenous Administration of Prostaglandin E2 and Oxytocin

Br Med J 1972; 4 doi: (Published 25 November 1972) Cite this as: Br Med J 1972;4:461
  1. William C. M. K. Naismith,
  2. Wallace Barr,
  3. J. MacVicar


    In a group of 20 matched primigravid patients labour was induced by forewater amniotomy followed by intravenous oxytocin (Syntocinon) administered in escalating doses. Ten of these patients, in a double-blind trial, also received prostaglandin E2 infused simultaneously with the oxytocin. In the combined prostaglandin-oxytocin group there was a noticeable reduction in the dosage of oxytocin required to produce effective uterine action, and the duration of labour was also reduced. No side effects were observed.