Papers And Originals

High Dosage Metolazone in Chronic Renal Failure

Br Med J 1972; 4 doi: (Published 28 October 1972) Cite this as: Br Med J 1972;4:196
  1. H. J. Dargie,
  2. Marjorie E. M. Allison,
  3. A. C. Kennedy,
  4. Mary J. B. Gray


    Metolazone is a modified quinazolinesulphonamide and in a dose of between 4 and 7·5 mg is an effective diuretic in man with normal renal function. Fourteen patients with non-oedematous stable chronic renal failure (creatinine clearance ranging from 1·2 to 12 ml/min) were given metolazone in doses ranging from 20-150 mg. A noticeable increase in urine flow and sodium excretion occurred, free water clearance increased, and there was a small but significant increase in potassium excretion. No side effects were noted.