Papers And Originals

Comparative Nephrotoxicity of Aspirin and Phenacetin Derivatives

Br Med J 1971; 4 doi: (Published 27 November 1971) Cite this as: Br Med J 1971;4:518
  1. I. C. Calder,
  2. C. C. Funder,
  3. C. R. Green,
  4. K. N. Ham,
  5. J. D. Tange


    Both aspirin and phenacetin derivatives were shown to be nephrotoxic when administered to rats as a single intravenous injection. Phenacetin derivatives tended to produce more severe renal damage and to be nephrotoxic in smaller doses than aspirin derivatives. With the exception of a single derivative, the renal lesions were confined to the proximal convoluted tubule, even after administration of compounds which under other conditions have induced renal papillary necrosis.