Papers And Originals

Secretory IgA in Urinary Tract Infections

Br Med J 1970; 4 doi: (Published 21 November 1970) Cite this as: Br Med J 1970;4:463
  1. Donald B. Kaufman,
  2. Roger Katz,
  3. Rawle M. McIntosh


    Secretory IgA, measured by radial immunodiffusion, was compared in the urine of children with chronic and recurrent non-obstructive urinary tract infections with that in normal children. IgA, IgG, and IgM were also measured. Absent and low levels of IgA(s) were found in both groups; however, the mean levels of IgA(s) were significantly higher in the infected group compared with normals—3·3 to 0·78 mg./24 hours, respectively. Secretory IgA was found to be locally produced in the bladder. It is suggested that IgA(s) levels reflect an antibody response to infection.