Papers And Originals

Hypotensive Action and Side Effects of Clonidine-Chlorthalidone and Methyldopa-Chlorthalidone in Treatment of Hypertension

Br Med J 1970; 4 doi: (Published 14 November 1970) Cite this as: Br Med J 1970;4:392
  1. A. Amery,
  2. M. Verstraete,
  3. H. Bossaert,
  4. G. Verstreken


    In an open, randomized, cross-over study the hypotensive action and side effects of clonidine-chlorthalidone and methyldopa-chlorthalidone combinations were compared. The diastolic morning blood pressure could be reduced to 95 mm. Hg or below in significantly more patients with clonidine than with methyldopa. Side effects, however, were more commonly encountered during the clonidine than during the methyldopa phase.