Intended for healthcare professionals

Papers And Originals

Osteomalacia with Long-term Anticonvulsant Therapy in Epilepsy

Br Med J 1970; 4 doi: (Published 10 October 1970) Cite this as: Br Med J 1970;4:69
  1. C. E. Dent,
  2. A. Richens,
  3. D. J. F. Rowe,
  4. T. C. B. Stamp


    The investigation and treatment of osteomalacia are described in four patients with epilepsy treated with long-term anticonvulsant therapy. It is suggested that drug-mediated enzyme induction may be the mechanism responsible by causing a greatly increased inactivation of vitamin D in these patients.