Papers And Originals

Critical study of 5% guanethidine in ocular manifestations of Graves's disease

Br Med J 1969; 4 doi: (Published 13 December 1969) Cite this as: Br Med J 1969;4:645
  1. N. E. F. Cartlidge,
  2. A. L. Crombie,
  3. J. Anderson,
  4. R. Hall


    Assessment was made of 5% local guanethidine in treating eye manifestations in euthyroid patients with either treated thyrotoxicosis or ophthalmic Graves's disease. In a double-blind crossover study guanethidine caused greater improvement in lid retraction than a control solution. A long-term study showed that this improvement was maintained. A much lower incidence of side-effects was noted with 5% guanethidine than with 10% solution.