Insulin sensitivity and vascular disease in maturity-onset diabeticsBr Med J 1969; 4 doi: https://doi.org/10.1136/bmj.4.5680.397 (Published 15 November 1969) Cite this as: Br Med J 1969;4:397
- A. E. Stocks,
- F. I. R. Martin
In 27 maturity-onset diabetics of more than 10 years' duration there was a significant tendency for both atherosclerosis and microangiopathy to be associated with a reduction in the acute hypoglycaemic effect of intravenous beef insulin. This finding is identical to that in a group of 51 insulin-dependent diabetics previously reported.
It is suggested that insulin insensitivity probably precedes the appearance of vascular disease in diabetes and may be implicated in its production.