Papers And Originals

Comparison of the Adrenocorticotrophic Activities of Two Synthetic Polypeptides: Synacthen and DW 75

Br Med J 1968; 4 doi: (Published 23 November 1968) Cite this as: Br Med J 1968;4:487
  1. W. W. Downie,
  2. K. Whaley,
  3. Mary A. Wright,
  4. Margaret A. Bell,
  5. Anne K. Taylor


    The adrenocorticotrophic activities of two synthetic polypeptides, Synacthen (Ciba) and DW 75 (Sandoz), were compared in two groups of patients having a variety of arthritic disorders. Compared with Synacthen, injected either intramuscularly or intravenously, intravenous DW 75 was found to have a longer duration of adrenocorticotrophic activity (measured by plasma 11-hydroxycorticosteroid levels) in both groups of patients, while intramuscularly administered DW 75 did not appear to be absorbed well.


    • * From the Centre for Rheumatic Diseases, Baird Street, and the University Department of Medicine, Royal Infirmary, Glasgow C.4.