Intended for healthcare professionals

Endgames Case Review

Golden brown pigmented rings in the eyes

BMJ 2024; 385 doi: https://doi.org/10.1136/bmj-2023-077962 (Published 11 April 2024) Cite this as: BMJ 2024;385:e077962
  1. Bangtao Yao, associate professor1,
  2. Jun Yang, neurologist2,
  3. Yong Zhang, radiologist3
  1. 1Department of Ophthalmology, Nanjing Lishui People’s Hospital, Zhongda Hospital Lishui branch, Southeast University, Nanjing, Jiangsu Province, China
  2. 2Department of Neurology, Nanjing Lishui People’s Hospital, Zhongda Hospital Lishui branch, Southeast University, Nanjing, Jiangsu Province, China
  3. 3Department of Medical Imaging, Nanjing Lishui People’s Hospital, Zhongda Hospital Lishui branch, Southeast University, Nanjing, Jiangsu Province, China
  1. Correspondence to: B Yao yaobamtao_njmu{at}163.com

A woman in her late 30s presented with golden brown lesions of both corneas during a routine ophthalmic examination. She had no ocular discomfort, systemic problems, history of alcohol consumption, or personal or family history of eye diseases. Her best corrected visual acuity was 20/20 in both eyes. On slit lamp examination, golden brown rings were visible at the edges of each cornea (fig 1). Anterior segment optical coherence tomography showed hyper-reflective bands on the periphery of each cornea at the level of Descemet’s membrane, indicating a Kayser-Fleischer ring. No other ocular abnormalities were detected.

Fig 1

Slit lamp examination showing golden brown rings (arrows) at the edge of each cornea (R=right eye; L=left eye)

Questions

  • 1 What is the most likely diagnosis?

  • 2 How would you manage this condition?

  • 3 What is the prognosis?

A

1 What is the most likely diagnosis?

Wilson’s disease—an autosomal recessive genetic disorder caused by mutations in the …

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