Intended for healthcare professionals


Valproate prescribing rules will tighten from January, says MHRA

BMJ 2023; 383 doi: (Published 29 November 2023) Cite this as: BMJ 2023;383:p2836
  1. Elisabeth Mahase
  1. The BMJ

From January 2024 valproate must not be started in new patients aged under 55 unless two specialists agree that there are no alternative options or that “compelling reasons” mean that the reproductive risks “do not apply,” the UK Medicines and Healthcare Products Regulatory Agency (MHRA) has said.1

The change is one of the first round of measures set to be put in place by the agency to reduce the known harms of valproate, including the “significant risk of serious harm to the baby if taken during pregnancy and the risk of impaired fertility in …

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