Intended for healthcare professionals


Covid-19: Vaccination plus infection offers best protection, finds study led by WHO

BMJ 2023; 380 doi: (Published 23 January 2023) Cite this as: BMJ 2023;380:p171
  1. Ingrid Torjesen
  1. The BMJ

“Hybrid immunity” derived from a mix of infection by SARS-CoV-2 and vaccination provides higher protection against reinfection than vaccination or infection alone, shows a systematic review published in Lancet Infectious Diseases.1 Its findings highlight the protective benefits of vaccination even after people have had covid-19.

Although, at 12 months from the beginning of assessment, protection against reinfection fell quickly to 41.8% (95% confidence interval to 31.5% to 52.8%), protection against hospital admission or severe disease remained high.

The findings showed that people with hybrid immunity were …

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