Preventing diabetes . . . and other storiesBMJ 2022; 376 doi: https://doi.org/10.1136/bmj.o77 (Published 20 January 2022) Cite this as: BMJ 2022;376:o77
Prediabetes is a label applied to people with evidence of impaired glucose metabolism but whose glucose or HbA1c levels aren’t high enough to meet diagnostic criteria for diabetes. An umbrella review reckons that prediabetes is associated with a 6% to 25% increase in mortality from all causes, and a higher incidence of cardiovascular disease, chronic kidney disease, cancer, and dementia. Mind you, many of the individual meta-analyses covered by the review were judged at high risk of bias (Diabetologia doi:10.1007/s00125-021-05592-3).
Long term outcomes of diabetes prevention
On the same subject, a long running investigation reports that neither lifestyle changes nor metformin made much difference …