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Covid-19: CoronaVac immunity is strongest after boosting with a different vaccine

BMJ 2022; 376 doi: (Published 25 January 2022) Cite this as: BMJ 2022;376:o210
  1. Luke Taylor
  1. Bogotá

A booster dose of a covid-19 jab other than CoronaVac significantly increased antibodies in those who had received two doses of the Chinese vaccine, a study funded by Brazil's Ministry of Health has found.

A booster dose of Pfizer Biontech’s mRNA vaccine boosted antibody levels the most, followed by Oxford AstraZeneca, Janssen, and a third dose of CoronaVac. All booster vaccines were effective and safe, concluded the researchers at the University of Oxford, who co-led the study published in the Lancet.1

The findings will guide governments on how to boost their populations’ immunity in the face of the more infectious omicron variant.

CoronaVac is manufactured by Chinese pharmaceutical Sinovac and is the world’s most administered coronavirus vaccine, making up two of the 10 billion vaccine doses given globally. A preprint study has found CoronaVac to be less effective than mRNA vaccines and …

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