Intended for healthcare professionals


NICE recommends progesterone to prevent early miscarriage

BMJ 2021; 375 doi: (Published 24 November 2021) Cite this as: BMJ 2021;375:n2896
  1. Jacqui Wise
  1. Kent

Progesterone should be offered to women who experience bleeding in early pregnancy and have previously had a miscarriage, the National Institute for Health and Care Excellence (NICE) has recommended.1

The new recommendation follows a Cochrane network meta-analysis of progestogens for preventing miscarriage. The committee found evidence of no benefit in women with early pregnancy bleeding but no previous miscarriage, nor in women with previous miscarriage but no early pregnancy bleeding in the current pregnancy. However, further research has been recommended in these two areas.

Miscarriage is a common complication of early pregnancy, affecting about 20% of all pregnancies. It can have serious consequences for patients, including psychological harm and mental health …

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