Causes of weight loss . . . and other storiesBMJ 2021; 375 doi: https://doi.org/10.1136/bmj.n2563 (Published 28 October 2021) Cite this as: BMJ 2021;375:n2563
Involuntary weight loss
In a retrospective analysis of 800 patients who presented to a clinic in northern Spain with involuntary weight loss, malignant disease was responsible for around 25% of cases. Non-malignant organic disease accounted for 45%, psychiatric disorder for 30%, and the cause was never identified in 3%. Overall, mortality at 12 months was 20%, although in the group with malignancy it was much higher at over 60% (PLoS One doi:10.1371/journal.pone.0257752).
Diagnosing Clostridioides difficile infection
Instead of relying on faecal culture to confirm infection with Clostridioides difficile, it might be better to focus on stool toxin concentrations. A study among 600 …