Calcification in arteries . . . and other storiesBMJ 2021; 374 doi: https://doi.org/10.1136/bmj.n1901 (Published 05 August 2021) Cite this as: BMJ 2021;374:n1901
Progression of aortic stenosis
There’s an inverse relation between calcification in arteries and calcification in bone. People with osteoporosis are at increased risk of arterial disease. However, treatments for osteoporosis seem to have little effect on blood vessel mineralisation. A randomised controlled trial of the bone resorption inhibitors denosumab and alendronate in people with aortic stenosis found no improvements in aortic valve calcium score or peak aortic jet velocities after two years of treatment (Circulation doi:10.1161/CIRCULATIONAHA.121.053708).
Adverse events in clinical trials
Serious adverse events in clinical trials of renin-angiotensin system blockers were about four times less common than adverse events in hypertensive patients getting similar treatment but not …