Should the UK vaccinate children and adolescents against covid-19?BMJ 2021; 374 doi: https://doi.org/10.1136/bmj.n1866 (Published 23 July 2021) Cite this as: BMJ 2021;374:n1866
- Sonia Saxena, professor of primary care1,
- Helen Skirrow, clinical NIHR doctoral research fellow1,
- Kate Wighton, media manager2
- 1Department of Primary Care and Public Health, Imperial College London, London W6 8RF
- 2Communications and Public Affairs, Imperial College London, London, UK
- Correspondence to: S Saxena
@soniaksaxena on Twitter
The UK Joint Committee on Vaccination and Immunisation (JCVI) has now recommended covid-19 vaccination for select groups of adolescents. Those newly eligible comprise 12-15 year olds with underlying conditions that may place them at increased risk of serious covid-19 infection, 17 year olds who are within three months of turning 18, and adolescents living with someone who is immunosuppressed.1 Young people aged 16 to 17 who are at higher risk of serious covid-19 were already eligible.
The decision came after the Medicines and Healthcare Products Regulatory Agency approved Pfizer-BioNTech’s covid-19 vaccine for use in children aged over 12 years.2 The JCVI decision triggered public debate because unlike several other high income countries, including the United States3 and Canada,4 the UK will not offer covid-19 vaccines to all children aged over 12 years.
The UK has vaccinated most of its high risk population against covid-19. Over two thirds of adults aged over 18 years have received two doses.5 However, breaking the chain of transmission needs close to 85% of the whole population to be immune.6 Children and adolescents, whose lives have been disrupted by school closures, isolation, and social restrictions,7 make up 21% of the population. As restrictions lift, cases are rising fast in this younger unvaccinated population.5
Benefits and risks
Extending covid-19 vaccination to protect adolescents aged 12 to 15 years with medical conditions such as Down’s syndrome seems justified, given their increased risk of severe infection.8 However, the vaccine offers less benefit for healthy adolescents, who tend to have a relatively mild illness. Their risk of death or hospital admission from covid-19 is very low; one study estimated the risk of catching and dying of covid-19 for all children in England as two in a million.9 Complications of covid-19 infection, including paediatric multisystem inflammatory syndrome, are also rare.10
Although most healthy adolescents recover after covid-19, some have reported persistent symptoms such as fatigue and headaches lasting 3-6 months.1112 Prevalence estimates for long covid vary, partly because symptoms are hard to separate from the wider effects of isolation and lockdowns on adolescents, but vaccination could reduce the health burden from long covid. Covid-19 vaccines reduce the risk of new variants emerging, and even a single dose can halve transmission rates.13 Thus vaccinating healthy adolescents could afford them better health while reducing disruption to their education and protecting social contacts.
Parents’ concerns centre around vaccine safety.14 Only half of parents of secondary school children say they would definitely want them to receive a covid-19 vaccination.5 The Pfizer-BioNTech vaccine trial in adolescents reported 100% efficacy at preventing covid-19 infection, without serious side effects.15 Regulatory agencies globally say vaccine benefits outweigh infection risks, and millions of over 12s have been vaccinated safely.316 A few vaccinated adolescents in the US and Israel have experienced heart inflammation (pericarditis and myocarditis).1718 The US Centers for Disease Control and Prevention confirmed 633 cases among the millions vaccinated to date.19 Most of the cases were mild and the young people recovered quickly.20
Even rare side effects among adolescents could undermine public trust in other lifesaving programmes such as human papillomavirus vaccination, which has reduced deaths from cervical cancer. Parents and teenagers should be reassured that any new vaccination programme is closely monitored and reports of side effects are quickly investigated. Parents should also be informed there are no plans to vaccinate children under 12 in the UK as there is currently insufficient evidence that vaccinating this age group is safe, effective, or acceptable to parents. However, trials are under way.
Young people have sacrificed their freedom in order to protect elderly relatives and family members. Yet from the start of the pandemic, 9 in 10 young people felt excluded from the covid-19 conversation by scientists and policy makers.21 Most young people aged 16-29 express willingness to be vaccinated against covid-19 if offered,5 though in the UK those aged 16 and 17 seem more cautious than people aged 18-24.22
Involving patients and the public in decisions about their health is an embedded core principle for health professionals. However, patient and public involvement has been largely missing from the pandemic response so far. Consulting young people and parents to understand their perspectives about getting the vaccine must now be a priority for a sustainable vaccination programme. This would also send a positive signal to the next generation that they are an integral part of society’s efforts to control the virus. By getting vaccinated, adolescents could protect themselves against the risk of long covid and help the UK’s control efforts. But they may prefer to wait their turn behind adults in other countries that have greater need.
Last week’s announcement for selective vaccination of adolescents seems justifiable given the benefits to adolescents and households at high risk of severe covid-19 infection, although it leaves the UK an outlier among rich countries. For now, decisions about mass vaccination of healthy adolescents will be guided by the pandemic’s impacts, and new data about the safety and effectiveness of vaccinating this age group. The effectiveness of any vaccine programme depends on uptake, so young people’s voices should be part of ongoing reviews of covid-19 policy. Today’s adolescents will make decisions about our health in years to come. We need to listen to them.
We thank the parents and young people who contributed to this editorial, commented on the content, and suggested revisions that helped frame our key messages, including Rosenna Sandbrook, Nina Pollok, Kim Foley, Rakhee Shah, Arti Maini, Amanda Young, and Maya Young.
Competing interests: The BMJ has judged that there are no disqualifying financial ties to commercial companies. The authors declare the following other interests. SS is supported by the NIHR Northwest London Applied Research Collaboration, NIHR School for Public Health Research and holds funding from the Daily Mile Foundation. HS is funded by an NIHR doctoral research fellowship number 300907. Further details of The BMJ policy on financial interests is here: https://www.bmj.com/sites/default/files/attachments/resources/2016/03/16-current-bmj-education-coi-form.pdf.
Provenance and peer review: Commissioned; not externally peer reviewed
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