How can we manage covid fatigue?
BMJ 2021; 373 doi: https://doi.org/10.1136/bmj.n1610 (Published 24 June 2021) Cite this as: BMJ 2021;373:n1610Read our latest coverage of the coronavirus pandemic
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Dear Editor
Dr Godlee appears to have unfortunately misunderstood the message on pacing from the ME/CFS community and charities.
Rather than, as she implies, it being a resigned surrender to life-long disability, it is a strategy for those who do not recover naturally to make the most of their limited capabilities without exacerbating their symptoms. [1, 2]
Given that, at the moment, we are unable to distinguish between those who will suffer from chronic energy limiting illness and those who will recover naturally given time, the safest way to do no harm is to advise those who suffer Post Exertional Malaise, also known as Post Exertional Symptom Exacerbation, to pace themselves.
Chronic conditions that develop following infections, whether viral or otherwise, have been long neglected, and research on behavioural techniques as treatments have failed to show any long-term benefit [3,4,5] in ME/CFS.
Hopefully the current focus on Long Covid will bring both effective treatment and understanding for all post-infection conditions - this will be made all the easier by positively engaging with patients and their representatives rather than misrepresenting them, accidentally or otherwise.
[1] https://meassociation.org.uk/about-what-is-mecfs/management/
[2] https://www.actionforme.org.uk/get-information/managing-your-symptoms/pa...
[3] “..the randomised treatment groups did not differ in mean fatigue scores at long-term follow-up..”,
‘Rehabilitative treatments for chronic fatigue syndrome: long-term follow-up from the PACE trial’, https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366%2815%290...
[4] “At LTFU there was no difference between the recovery rates for the different treatment strategies..”,
‘Internet-Based Therapy for Adolescents With Chronic Fatigue Syndrome: Long-term Follow-up’, https://pediatrics.aappublications.org/content/131/6/e1788
[5] ‘What long-term follow-up data tell us about the evidence on GET and CBT’, May 27, 2021. ME/CFS Skeptic. Blog.
Competing interests: No competing interests
Dear Editor
Neurology of COVID-19 Fatigue
With COVID-19 infection, fatigue can present in the mild early stages, during the severe clinical condition and in the post COVID-19 period.
Fatigue is one of the most common (38% to 55%) symptoms in the early stage and it is most persistent and debilitating in many people with COVID-19 infection.
Fatigue can be due to central, psychological, and/or peripheral mechanisms due to the COVID-19.
Many factors can contribute to fatigue with Covid-19 infection, which include changes in neurotransmitter levels, inflammation, psychological disorders, stress levels, cognitive dysfunction, impaired oxygen delivery to the brain, and skeletal muscle involvment.
The central factors influencing COVID-19 fatigue may be a result of the virus invading the central nervous system directly. Other central factors which may also contribute to COVID-19 fatigue include changes in neurotransmitter levels (e.g., dopamine and serotonin), intrinsic neuronal excitability, demyelination (resulting in changes in axonal conduction velocity), and many others.
The recent functional neuroimaging studies in COVID-19 patients have also demonstrated frontal hypometabolism and cerebellar hypermetabolism, which may also have an impact on fatigue.
In the periphery, COVID-19 may directly impact the skeletal muscle and, therefore, contribute to fatigue.
Various skeletal muscle cell types may independently and/or collectively show vulnerability to COVID-19 via angiotensin-converting enzyme 2 (ACE2). COVID-19 in the lungs activates various leukocytes to release a cascade of cytokines, including interleukin-6 (IL-6). Notably, systemic elevations of IL-6 can also disrupt the muscle metabolic homeostasis and exacerbate the muscle loss and can cause fatigue.
Competing interests: No competing interests
Dear Editor,
I hope that you are in the best of health and staying safe! While I do agree with many points in your article, I must admit that the rather dreary outlook, though a realistic one, is not necessarily a complete depiction of how we have been adjusting to the overstaying visitor that SARS-CoV2 has become.
As we traipse further along the turbulent tracks of the COVID-19 pandemic, entering a spring-time scene of cautious optimism, we see many changes that once seemed temporary beginning to enter a more everlasting part of our daily existence. We’ve seen the normalization of online events, meetings, and education; the rise of vaccine acceptance and a shift in the delivery of healthcare. With this in mind, we look to the meteoric rise and acceptance of telemedicine.
Telemedicine is ‘the use of technology (computers, video, phone, messaging) by a medical professional to diagnose and treat patients in a remote location.’ [1] Though not a new concept, a survey by the Royal College of GPs found that six in 10 appointments in mid-July [2020] were conducted by telephone. [2]
As we see telemedicine becoming the norm, with clinic days in a general hospital setting being mostly via phone or online, we see the success of technology aiding us in the face of adversity. There are many advantages to this. Firstly, it is convenient. Patients can discuss their condition and follow up with their health care providers from the comfort of their homes. Through this we also see an improvement in the access to healthcare as well as increased adherence and attendance to scheduled appointments. Furthermore, it is cost effective. Patients spend less time and money reaching to and being in the hospital itself. [3] When Covid-19 hit, we (doctors) were instructed to discourage patients from entering the practice physically in order to keep them and the staff safe. [2] Keeping this in mind, there is less exposure to illness and infections for both the patient and the healthcare provider with telemedicine. [3]
There are, however, some downsides to this. Whilst technology is constantly making gargantuan strides that we are evolving and adapting to daily, it is sometimes easy to forget that not everyone can use technology or may have difficulties in doing so, particularly older patients. While the accessibility is increased for doctor-patient interaction and flow, this may not apply to all age groups. Through this, we also see the aspect of physical examination removed from an average consultation and doctors must rely on self-reporting from the patient. [3] Ethically, a patient has autonomy over how they are treated, and the decisions made for them (assuming that they are compos mentis and taking their respective situation into consideration). But what happens when there is incongruity between what the patient is describing to their doctor and what the patient’s actual diagnosis is. Long-term COVID is an uncharted territory for all healthcare workers, with idiosyncrasies that range a multitude of systems and symptoms. And while every doctor makes a vow to do no harm, what precautions can be taken when a condition is to be treated without a face-to-face interaction, inappropriate description or ignorance due to sheer lack of knowledge.
As telemedicine becomes more commonplace, as with any technological advancement that is accessible that also affects the general population, we also see the introduction of guidance and guidelines coming into play. Guides, such as the ones that are available on the Irish Medical Council’s website, contain information and practical advice for doctors who now utilise telemedicine systems for a large proportion of consultations. [4] It would not be unwise to assume that workshops for effective telemedicine communication could soon be introduced, and even introduced into medical curricula.
The field of healthcare is a periscope in which we are privileged to see inside the lives of the people around us. We see that their condition doesn’t define them but is only a fragment of their multifaceted life. But when a patient becomes a mere voice on the phone, with a complaint or condition, it shows us that we are often limited as doctors in improving the patient holistically rather than just trying to alleviate their ailments. And with COVID, we've seen these deficits highlighted. Through lack of inappropriate management, lack of efficiency in implementing regulations, and the ever-increasing burden on healthcare workers and patients. To quote Plato, if 'necessity is the mother of invention,' whilst technology has greatly aided us to overcome some of the physical barriers that the pandemic has presented, one must wonder, at what cost?
Which is why, dear editor, whilst I completely agree with your statement on how 'the pressure on healthcare systems and staff is causing moral distress and injury', with overworked, underpaid and under-appreciated employees moving away from healthcare, perhaps, as we move towards our inevitable freedom, we can take a fraction of solace in the medical advancements we've made during these tumultuous times. With vaccinations and voracious adaptations to the whims of a virus that cannot be viewed, perhaps one day we can look back on this era of healthcare with valediction.
References:
1. Chiron Health, (2021). What is Telemedicine?.
2. Stokel-Walker C.. Why telemedicine is here to stay. BMJ 2020;371:m3603(): doi: https://doi.org/10.1136/bmj.m3603 (accessed ).
3. Medical News Today, (2020.) Telemedicine benefits: For patients and professionals. https://www.medicalnewstoday.com/articles/telemedicine-benefits (accessed ).
4. The Medical Independent, (2020.) Medical Council releases new telemedicine guide for doctors. Available at : https://www.medicalindependent.ie/medical-council-releases-new-telemedic... Medical Independent.
Competing interests: No competing interests
Replete essential nutrient deficiencies Re: How can we manage covid fatigue?
Dear Editor
Professor Aleem responds that COVID-19 fatigue may be a result of the virus invading the central nervous system directly but other central factors may include changes in neurotransmitter levels. Serotonin and dopamine are metabolised by monoamine oxidases (MAO) and catechol-O-methyl transferase (COMT) which need zinc and copper cofactors.
McLaren-Howard, Myhill and Booth have proved that the Chronic Fatigue Syndrome (Post Viral Syndrome or Myalgic Encephalomyelitis) is due to mitochondrial dysfunction and deficiencies of essential nutrients.[1-3]
Unfortunately essential nutrient deficiencies of zinc, copper, magnesium and B vitamins are very common, especially in women taking progestogens and/or oestrogens for contraception or HRT.[4] The result is more women than men develop mitochondrial dysfunction and therefore the Chronic Fatigue Syndrome (CFS).
Dr John McLaren-Howard has also shown severe impairment of muscle function with low red cell magnesium levels.[5]
1 Sarah Myhill, Norman E Booth, John McLaren-Howard. Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit.
Int J Clin Exp Med.2013;6(1): 1–15.Published online 2012 Nov 20.
2 Norman E Booth, Sarah Myhill, John McLaren-Howard. Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Int J Clin Exp Med.2012;5(3): 208–220.Published online 2012 Jun 15.
3 Sarah Myhill, Norman E. Booth, John McLaren-Howard. Chronic fatigue syndrome and mitochondrial dysfunction. Int J Clin Exp Med.2009;2(1): 1–16.Published online 2009 Jan 15.
4 Grant ECG. The pill, hormone replacement therapy, vascular and mood over-reactivity, and mineral imbalance. J Nutr Environ Med 1998;8:105-116.
5 John McLaren-Howard. Muscle action, trace elements and related elements: the myothermogram. in Chazot Gea,ed. Current Trends in Trace Element Research.. Smith-Gordon, 1989.
Competing interests: No competing interests